Prof. Dr. Norbert Graf

Pediatric Oncology

Medicine is undergoing a paradigm shift from phenotyping to genotyping. An open modular architectural framework for tools, models, and services together with a legal framework for data privacy and data security is developed in different European projects in cooperation between basic scientists, clinicians, informaticians and modellers as well as ethicist and lawyers. Models using AI for different cancer types are developed to foster translational medicine. One of the cancer types is nephroblastoma, the most common kidney cancer in childhood.The developed model for nephroblastoma is clinically driven to enhance decision support. This is guaranteed by an IT infrastructure that is able to handle and share heterogeneous data sets composed of clinical, imaging and basic research data. The infrastructure enables standardization and semantic data interoperability and can integrate the developed models. A legal framework ensures data protection and privacy by implementation of policies for accessing data, services, tools, and models.